Posts Tagged ‘medicine’

Problematic prions and the history of Mad Cow Disease

Well, folks, it has happened again. A dairy cow from California was recently diagnosed with bovine spongiform encephalopathy (BSE), also known as “mad cow disease.” The cow was already at a rendering plant when the diagnosis was made and, apparently, was never headed toward our food supply. The last confirmed BSE infection in US beef was in 2006, and in total, only four cows have ever tested positive in our country’s entire beef industry. Meanwhile, in just a handful of decades, over a hundred people in the UK have gone “mad” and ultimately died from consuming BSE-tainted beef. In addition, over four million head of cattle have been culled in the UK in an effort to eradicate the problem.

The history of spongiform encephalopathy, however, begins long before the relatively recent BSE crisis — and its victims have included everything from human cannibals to farmed mink. Yet, rarely does science news cover spongiform encephalopathy beyond the context of the grilled burger patty. Burgers are indeed delicious (I prefer mine with BBQ sauce and cheddar cheese), but trust me, the history of spongiform encephalopathy as a disease is way more interesting than this one dairy cow might lead you to believe.

Circa 1920, two German doctors, Hans Gerhard Creutzfeldt and Alfons Maria Jakob, each individually identified the symptoms of spongiform encephalopathy in humans. Hence, the pathology was named Creutzfeldt-Jakob disease (CJD) in their honor. The patients that the doctors studied, however, did not develop their diseases as a result of eating tainted beef. Rather, these patients “spontaneously” developed the condition as the result of a rare (and natural!) genetic anomale.


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Research shows that alcohol drowns sorrows – in fruit flies

“Tony” did everything he could to get the pretty red-eyed girl.  He chased her into the corner, tapped her abdomen with his forelegs, serenaded her with his single-winged song, and even licked her genitalia. Despite a perfect performance of this hard-wired mating dance, he was rejected.

Like any good cowboy in a sad country song, Tony turned to the bottle. But unlike most cowboys, Tony is a fly.

New research shows that humans aren’t the only species to turn to alcohol after social or sexual rejection. The paper Sexual Deprivation Increases Ethanol Intake in Drosophila, published last month in Nature, explores the influence of reward pathways on sex, drugs and social interactions — and gives a whole new meaning to the term “barfly.”

The brain’s reward system is designed to reinforce behaviors necessary for survival. Both natural “highs” and highs that result from drug intake can trigger this reward system.  Abnormal regions within reward pathways are often associated with addiction.


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The cutting edge in modern organ transplantation, from livers to faces

Richard Norris was recently the recipient of the most extensive face transplant ever performed. He was injured over 15 years ago in a shooting accident that caused tremendous damage to his jaw structure, nose, and tongue. After 36 hours of surgery, Mr. Norris now has an entirely new face, including a new jaw, new teeth, a new tongue, and a new nose. He is even shaving his new beard.

Mr. Norris’ surgery was funded by the U.S. Navy. In recent years, the military has invested substantially in reconstructive medicine, funding scores of face and hand transplants on civilians. Meanwhile, there are hundreds of recent war veterans who have returned home with severe facial wounds and countless more amputees. The hope for the military is that extreme transplant surgeries for faces and limbs will soon be available for these military veterans as well.


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