Posts by Chris Holdgraf

Technology reveals science that the naked eye cannot admire

One of the reasons that fields such as biology and chemistry can be difficult for non-scientists to understand is that the objects and processes they study are far too small to be seen with the naked eye.  Envisioning what something like endocytosis might look like is as much an exercise in creativity as reality. However, technology is beginning to bridge this gap, and the result is every bit as fascinating as we could have imagined.

At the University of Cambridge, the “Under the Microscope” project aims to detail the beauty and complexity of biology at its tiniest.  Take, for example, this image of a “Killer T-cell” attacking a cancerous cell in the body:


http://www.youtube.com/watch?feature=player_embedded&v=jgJKaP0Sj5U

In this video, we see the Killer T-cell (in green) identify and attack a cancerous cell beneath it (in blue).  While watching it, two things immediately came to my mind.  One was the accuracy of the T-cell in carrying out its duty of destroying the cancerous cell.  The environment was filled with all kinds of tiny cellular neighbors, and yet our hero knew what to aim for and how to get there.


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John Snow and the cholera outbreak of 1854: Revealing an unintuitive truth using data

Truth reveals itself to us in many different ways. Sometimes, it takes the form of an amazing revelation, an eye-catching explosion of color, or a terrifying act of nature. Other times, it takes on a more subtle form, discovered only through a combination of patience, knowledge, and determination.

Turn the clock back a few hundred years, and you would find a culture that did not have the sophisticated data analysis techniques to uncover the truths of natural world that we have today.  Claims were often backed up by “common sense”.  Society lacked a way of quantifying information and letting the data speak for itself. But this mentality began to change in the 1800s, marking an important shift in our scientific culture that continues to this day.  While the process spanned several generations and countless individuals, one of the more interesting stories is that of a man named John Snow.


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Piecing together the past at IceCube


I’d like all of you to try something before reading this article: go outside (or, if you live in the Bay Area, you may have to settle for your fridge), and take a look a a piece of ice. Doesn’t seem to be much going on there, huh? Well, what if I told you that you could measure energy that originated from the creation of the universe using that piece of ice? Setting aside my possible insanity as an answer, you’d probably want a good explanation. Well, without further ado, allow me to explain…

How to see the history of the universe with a piece of ice:

Step 1: raise $271 million in venture capital.
Step 2: build a giant lepton detector in the south pole.
Step 3: record the energy released by sub-atomic collisions originating from the creation of the universe

See how easy that was?

Even if you’re unable to carry out this little experiment by yourself, it turns out you’re in luck because someone else is already trying it. I’m referring to the IceCube Neutrino Observatory, located in Antarctica.  It’s run by researchers at the University of Wisconsin – Madison and aims to tell us something about the distant (and I mean distant) past by measuring the energy emitted in ice deep within the south pole.


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